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Case Reports
. 2014 Nov;3(6):732-4.
doi: 10.1016/j.msard.2014.08.001. Epub 2014 Aug 15.

Glatiramer acetate-induced hepatitis in a young female patient with multiple sclerosis

Sara La Gioia  1 , Giuseppe Bacis  2 , Aurelio Sonzogni  3 , Barbara Frigeni  4 , Marta Zaffira Conti  4 , Marcella Vedovello  4 , Mariarosa Rottoli  4
Affiliations
Case Reports

Glatiramer acetate-induced hepatitis in a young female patient with multiple sclerosis

Sara La Gioia et al. Mult Scler Relat Disord. 2014 Nov.

Abstract

We report the first Italian case of glatiramer acetate-related acute hepatotoxicity. A 25-years-old woman suffering from multiple sclerosis presented acute hepatitis after eight months of treatment. Neither infective, nor autoimmune markers were detected. Liver biopsy histology was consistent with drug-induced acute injury. Liver function tests became normal after eight weeks of treatment discontinuation. This report points out the importance of monitoring liver function during the first year of treatment with glatiramer acetate.

Keywords: Glatiramer acetate; Hepatitis; Multiple sclerosis; Toxicity.

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