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. 2015 Mar 1;4(2):191-202.
doi: 10.1039/C4TX00127C.

Manganese-induced Neurotoxicity: From C. elegans to Humans

Pan Chen  1 , Sudipta Chakraborty  1 , Tanara V Peres  2 , Aaron B Bowman  3 , Michael Aschner  1
Affiliations

Manganese-induced Neurotoxicity: From C. elegans to Humans

Pan Chen et al. Toxicol Res (Camb). .

Abstract

Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.

Keywords: Parkinson's disease; manganese; manganism; neurodegeneration; neurotoxicity.

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References

    1. ATSDR. Toxicological profile for manganese (Draft for Public Comment) U.S Department of Health and Human Services, Public Service. 2008
    1. Tuschl K, Mills PB, Clayton PT. Manganese and the brain. Int Rev Neurobiol. 2013;110:277–312. - PubMed
    1. Jitrapakdee S, et al. Structure, mechanism and regulation of pyruvate carboxylase. Biochem J. 2008;413:369–87. - PMC - PubMed
    1. Kanyo ZF, Scolnick LR, Ash DE, Christianson DW. Structure of a unique binuclear manganese cluster in arginase. Nature. 1996;383:554–7. - PubMed
    1. Paul A, et al. Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Mech Ageing Dev. 2007;128:706–16. - PMC - PubMed