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Review
. 2015 Aug;34(8):1487-93.
doi: 10.1007/s10096-015-2379-9. Epub 2015 Apr 18.

Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade

G Meletis  1 , D Chatzidimitriou, N Malisiovas
Affiliations
Review

Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade

G Meletis et al. Eur J Clin Microbiol Infect Dis. 2015 Aug.

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.

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