[Expression of Mycobacterium tuberculosis small RNAs in mice models of tuberculosis]

Abstract

Identification of mechanisms that contribute to bacterial pathogens survival in the infected organism is a powerful approach to influence the pathogenic bacteria. Recently it was established that bacteria use small RNAs to regulate their metabolism. We studied the expression level of the three most highly expressed M. tuberculosis small RNAs MTS0997, MTS 1338 and MTS2823 at different stages of infection in. mice with different genetic resistance to tuberculosis. The maximum expression level of these small RNAs was observed at the early stages of infection.