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Case Reports
. 2015;134(2):71-5.
doi: 10.1159/000371831. Epub 2015 Apr 18.

Emerging BCR/ABL1 Mutations Under Treatment with Tyrosine Kinase Inhibitors in Paediatric Acute Lymphoblastic Leukaemia

Agueda Molinos-Quintana  1 , Virginia Aquino, Isabel Montero, Concepción Pérez-de Soto, Raúl García-Lozano, José Antonio Pérez-Simón, José María Pérez-Hurtado
Affiliations
Case Reports

Emerging BCR/ABL1 Mutations Under Treatment with Tyrosine Kinase Inhibitors in Paediatric Acute Lymphoblastic Leukaemia

Agueda Molinos-Quintana et al. Acta Haematol. 2015.

Abstract

We report on the emergence and clinical relevance of an unusual BCR-ABL1 kinase domain mutational status in a 2-year-old female with p210-BCR-ABL Philadelphia chromosome-positive acute lymphoblastic leukaemia. We detected three BCR-ABL1 clones determined by the presence of the E255V, D276G and F317L mutations. We point out the usefulness of searching for mutated populations that survive tyrosine-kinase inhibitor therapy and the role of their clonal selection over time in relation to therapeutic intervention.

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