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Case Reports
. 2015 Dec;9(4):530-3.
doi: 10.1007/s12105-015-0628-y. Epub 2015 Apr 21.

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Orhun Cig Taskin  1 , Hasan Gucer  1   2 , Daniel Winer  1   2 , Ozgur Mete  3   4
Affiliations
Case Reports

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Orhun Cig Taskin et al. Head Neck Pathol. 2015 Dec.

Abstract

Xanthogranulomatous inflammation (XGI) is an uncommon destructive chronic inflammatory process mainly occurring in the kidney and gallbladder, characterized by the accumulation of foamy histiocytes, multinucleated giant cells (Touton type), cholesterol clefts and chronic inflammatory cells. The head and neck region is an uncommon site for XGI. This type of inflammatory reaction has been defined in branchial cleft cyst, salivary gland tumors following fine-needle aspiration biopsies, Rathke's cleft cyst in the pituitary gland, and colloid cyst in the 3rd ventricle. We present herein a unique case of ruptured thyroglossal duct cyst leading to XGI, characterized by an infiltrative subcutaneous central neck lesion, clinically mimicking a thyroid carcinoma. In addition, we also summarize current insights into the pathogenesis of XGI in the head and neck region.

Keywords: Head and neck; Thyroglossal duct cyst; Xanthogranulomatous inflammation.

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Figures

Fig. 1
Fig. 1
Histopathological examination of the Sistrunk specimen revealed a ruptured cystic lesion lined predominantly by bland squamous epithelium and contained abundant proteinaceous material along with cholesterin crystals and macrophages (a–c). The surrounding connective tissue showed scattered thyroid follicles (d) admixed with an inflammatory process characterized by foamy histiocytes as well as Touton type giant cells (e, f)
See this image and copyright information in PMC

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