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Review
. 2015 Apr 7:11:975-82.
doi: 10.2147/NDT.S80480. eCollection 2015.

Neuromodulation and antenatal depression: a review

Deborah R Kim  1 , Jessica L Snell  1 , Grace C Ewing  1 , John O'Reardon  2
Affiliations
Review

Neuromodulation and antenatal depression: a review

Deborah R Kim et al. Neuropsychiatr Dis Treat. .

Abstract

Background: Depression during pregnancy affects 5%-8% of women. While the percentage of women in the US taking serotonin reuptake inhibitors during pregnancy has risen over the last decade, pregnant women continue to report that they prefer non-pharmacologic interventions.

Objective: We review the literature regarding neuromodulation techniques for major depressive disorder during pregnancy. The rationale for their use in this population, new developments, and future directions are discussed.

Methods: A literature search was conducted in PubMed Plus, Ovid Medline, and Embase to collect all articles on neuromodulation for the treatment of depression during pregnancy. Key search words included electroconvulsive therapy, transcranial magnetic stimulation, deep brain stimulation, transcranial direct current stimulation, neuromodulation, depression, and pregnancy. Given the sparse literature, all articles from 1960 to 2014 that addressed the use of neuromodulation in pregnancy were included.

Conclusion: The data support the use of electroconvulsive therapy in all trimesters of pregnancy for major depressive disorder. New data are emerging for the use of transcranial magnetic stimulation in pregnancy, which is likely safe, but more data are needed before it can be recommended as a primary treatment modality during pregnancy. Other neuromodulation techniques have not been well studied in this population.

Keywords: antenatal depression; depression; electroconvulsive therapy; perinatal; pregnancy; transcranial magnetic stimulation.

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References

    1. George MS, Nahas Z, Borckardt JJ, et al. Brain stimulation for the treatment of psychiatric disorders. Curr Opin Psychiatry. 2007;20(3):250–254. discussion 247–249. - PubMed
    1. Radhu N, de Jesus DR, Ravindran LN, Zanjani A, Fitzgerald PB, Daskalakis ZJ. A meta-analysis of cortical inhibition and excitability using transcranial magnetic stimulation in psychiatric disorders. Clin Neurophysiol. 2013;124(7):1309–1320. - PubMed
    1. Schlaepfer TE, Bewernick BH. Neuromodulation for treatment resistant depression: state of the art and recommendations for clinical and scientific conduct. Brain Topogr. 2014;27(1):12–19. - PubMed
    1. Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR. Prevalence of depression during pregnancy: systematic review. Obstet Gynecol. 2004;103(4):698–709. - PubMed
    1. Marcus SM, Flynn HA, Blow F, Barry K. A screening study of antidepressant treatment rates and mood symptoms in pregnancy. Arch Womens Ment Health. 2005;8(1):25–27. - PubMed

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