. 2015 Apr 22;17(1):107.

doi: 10.1186/s13075-015-0618-1.

Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study

Andrew J Teichtahl^{1

2}, Yuanyuan Wang³, Sam Smith⁴, Anita E Wluka⁵, Donna Urquhart⁶, Graham G Giles^{7

8

9}, Sultana Monira Hussain¹⁰, Flavia M Cicuttini¹¹

Affiliations

¹ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
² Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
³ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. yuanyuan.wang@monash.edu.
⁴ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. sesmi8@student.monash.edu.au.
⁵ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. anita.wluka@monash.edu.
⁶ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. donna.urquhart@monash.edu.
⁷ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.
⁸ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3053, Australia. graham.giles@cancervic.org.au.
⁹ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.
¹⁰ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. monira.hussain@monash.edu.
¹¹ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. Flavia.cicuttini@monash.edu.

PMID: 25897761
PMCID: PMC4462003
DOI: 10.1186/s13075-015-0618-1

Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study

Andrew J Teichtahl et al. Arthritis Res Ther. 2015.

. 2015 Apr 22;17(1):107.

doi: 10.1186/s13075-015-0618-1.

Authors

Andrew J Teichtahl^{1

2}, Yuanyuan Wang³, Sam Smith⁴, Anita E Wluka⁵, Donna Urquhart⁶, Graham G Giles^{7

8

9}, Sultana Monira Hussain¹⁰, Flavia M Cicuttini¹¹

Affiliations

¹ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
² Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
³ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. yuanyuan.wang@monash.edu.
⁴ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. sesmi8@student.monash.edu.au.
⁵ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. anita.wluka@monash.edu.
⁶ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. donna.urquhart@monash.edu.
⁷ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.
⁸ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3053, Australia. graham.giles@cancervic.org.au.
⁹ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.
¹⁰ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. monira.hussain@monash.edu.
¹¹ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. Flavia.cicuttini@monash.edu.

PMID: 25897761
PMCID: PMC4462003
DOI: 10.1186/s13075-015-0618-1

Abstract

Introduction: Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. This study examines whether the body mass index (BMI) and body composition are associated with hip cartilage changes using magnetic resonance imaging (MRI) in community-based adults.

Methods: 141 community-based participants with no clinical hip disease, including OA, had BMI and body composition (fat mass and fat free mass) measured at baseline (1990 to 1994), and BMI measured and 3.0 T MRI performed at follow-up (2009-2010). Femoral head cartilage volume was measured and femoral head cartilage defects were scored in the different hip regions.

Results: For females, baseline BMI (β = -26 mm(3), 95% Confidence interval (CI) -47 to -6 mm(3), p = 0.01) and fat mass (β = -11 mm(3), 95% CI -21 to -1 mm(3), p = 0.03) were negatively associated with femoral head cartilage volume. Also, while increased baseline fat mass was associated with an increased risk of cartilage defects in the central superolateral region of the femoral head (Odds Ratio (OR) = 1.08, 95% CI 1.00-1.15, p = 0.04), increased baseline fat free mass was associated with a reduced risk of cartilage defects in this region (OR = 0.82, 95% CI 0.67-0.99; p = 0.04). For males, baseline fat free mass was associated with increased femoral head cartilage volume (β = 40 mm(3), 95% CI 6 to 74 mm(3), p = 0.02).

Conclusions: Increased fat mass was associated with adverse hip cartilage changes for females, while increased fat free mass was associated with beneficial cartilage changes for both genders. Further work is required to determine whether modifying body composition alters the development of hip OA.

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Figures

**Figure 1**
Regional zones of the hip joint. **(A)** Sagittal image depicting the anterior, central and posterior regions. **(B)** Coronal image depicting the central superolateral (CSL) and inferomedial (CIM) regions.

See this image and copyright information in PMC

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Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study

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Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study

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