Therapeutics and vaccines against chikungunya virus
- PMID: 25897811
- DOI: 10.1089/vbz.2014.1681
Therapeutics and vaccines against chikungunya virus
Erratum in
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Correction to: Vector Borne Zoonotic Dis 2015;15(4):250-257 DOI: 10.1089/vbz.2014.1681.Vector Borne Zoonotic Dis. 2015 Nov;15(11):712. doi: 10.1089/vbz.2015.29992.ta. Vector Borne Zoonotic Dis. 2015. PMID: 26565776 No abstract available.
Abstract
Currently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV), and these were subjects discussed during a CHIKV meeting recently organized in Langkawi, Malaysia. In this review, we chart the approaches taken in both areas. Because of a sharp increase in new data in these fields, the present paper is complementary to previous reviews by Weaver et al. in 2012 and Kaur and Chu in 2013 . The most promising antivirals so far discovered are reviewed, with a special focus on the virus-encoded replication proteins as potential targets. Within the vaccines in development, our review emphasizes the various strategies in parallel development that are unique in the vaccine field against a single disease.
Keywords: Antibodies; Antiviral; Attenuated virus; Chikungunya; DNA chimeric viruses; Polymerase; Protease; Vaccine; Virus-like particles.
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