Zero tolerance: amphipathic helices in endocytosis

Abstract

Endocytosis is the physical battle to form a new vesicle in the face of counteracting forces, such as membrane tension. Skruzny et al. (2015) and Miller et al. (2015) now shed light on endocytic proteins that bear a "Helix 0" and on the proteins' role in the struggle to make clathrin-coated vesicles.