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Comment
. 2015 Apr 20;33(2):122-4.
doi: 10.1016/j.devcel.2015.04.005.

Crumbling under pressure

Frank M Mason  1 , Adam C Martin  2
Affiliations
Free article
Comment

Crumbling under pressure

Frank M Mason et al. Dev Cell. .
Free article

Abstract

In order for an organism to maintain its form, it must be able to withstand physical perturbation, including the pull of gravity. A recent study in Nature from Porazinski and colleagues (2015) suggests that mechanisms promoting tissue tension are critical to resist the Earth's downward pull.

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  • YAP is essential for tissue tension to ensure vertebrate 3D body shape.
    Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, Hata S, Sasaki T, Krens SFG, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M. Porazinski S, et al. Nature. 2015 May 14;521(7551):217-221. doi: 10.1038/nature14215. Epub 2015 Mar 16. Nature. 2015. PMID: 25778702 Free PMC article.

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