[In vitro detection of ovalbumin-specific IgA producing cells from lymphocytes of patients with hen-egg allergy]
[Article in
Japanese]
- PMID: 2589970
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[In vitro detection of ovalbumin-specific IgA producing cells from lymphocytes of patients with hen-egg allergy]
[Article in
Japanese]
Arerugi.
1989 Oct.
Abstract
We studied antigen-specific IgA production from the peripheral lymphocytes of children with hen-egg allergy by using the method of indirect plaque forming cell (PFC) assay. The number of OVA-specific IgA-PFC generated from the patient lymphocytes was low (6 +/- 3/7 X 10(4) non T cells) in comparison with age-matched normal children (112 +/- 18/7 X 10(4) non T cells). The numbers of OVA-specific IgG-PFC and IgM-PFC generated from the patient lymphocytes were not so different from those of the age-matched normal children. This indicates that the activity of OVA-specific IgA-antibody production was reduced in patients with hen-egg allergy.
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