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. 2015 May;203(5):379-86.
doi: 10.1097/NMD.0000000000000295.

Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Camice J Revier  1 , Ulrich Reininghaus, Rina Dutta, Paul Fearon, Robin M Murray, Gillian A Doody, Tim Croudace, Paola Dazzan, Margaret Heslin, Adanna Onyejiaka, Eugenia Kravariti, Julia Lappin, Ben Lomas, James B Kirkbride, Kim Donoghue, Craig Morgan, Peter B Jones
Affiliations

Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Camice J Revier et al. J Nerv Ment Dis. 2015 May.

Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

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Figures

FIGURE 1
FIGURE 1
Time to first remission and illicit drug use at baseline; rates of mortality by cause.
FIGURE 2
FIGURE 2
Family involvement at first contact; rates of mortality by cause.
FIGURE 3
FIGURE 3
ÆSOP-10 study clinical course and outcome.
See this image and copyright information in PMC

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