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Review
. 2015 Apr 21;131(16):1435-47.
doi: 10.1161/CIRCULATIONAHA.115.013894.

Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload

Gabriele G Schiattarella  1 , Joseph A Hill  2
Affiliations
Review

Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload

Gabriele G Schiattarella et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
Canonical “three stages” model of hypertrophic transformation of the heart. This model posits “short-term” hypertrophy as a beneficial event and “long-term” hypertrophy as detrimental.
Figure 2
Figure 2
Model of the hypertrophic response to toxic stress. We propose that hypertrophic transformation of the heart under stress is similar to other biological processes which evolved to provide short-term benefit. These include activation of the β-adrenergic and renin-angiotensin-aldosterone axes. Cornerstone therapy for heart failure involves interruption of these responses, and we suggest that judicious suppression of hypertrophy may provide similar benefit.
See this image and copyright information in PMC

Comment in

  • Response to Schiattarella and Hill.
    Crozatier B, Ventura-Clapier R. Crozatier B, et al. Circulation. 2015 Apr 21;131(16):1447. Circulation. 2015. PMID: 26082962 No abstract available.

References

    1. Hill JA, Olson EN. Cardiac plasticity. N Engl J Med. 2008;358:1370–80. - PubMed
    1. Hill JA, Olson EN. Muscle: Fundamental Biology and Mechanisms of Disease. 2012:1528.
    1. Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation. 2013;128:388–400. - PMC - PubMed
    1. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart: a new therapeutic target? Circulation. 2004;109:1580–9. - PubMed
    1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–6. - PubMed

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