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Randomized Controlled Trial
. 2015 May;25(2):145-53.
doi: 10.1016/j.thorsurg.2014.11.002. Epub 2015 Feb 2.

Results of the national lung cancer screening trial: where are we now?

Neel P Chudgar  1 , Peter R Bucciarelli  1 , Elizabeth M Jeffries  1 , Nabil P Rizk  1 , Bernard J Park  1 , Prasad S Adusumilli  1 , David R Jones  2
Affiliations
Randomized Controlled Trial

Results of the national lung cancer screening trial: where are we now?

Neel P Chudgar et al. Thorac Surg Clin. 2015 May.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Thorac Surg Clin. 2020 May;30(2):xi. doi: 10.1016/j.thorsurg.2020.02.002. Thorac Surg Clin. 2020. PMID: 32327182 No abstract available.

Abstract

The National Lung Screening Trial was a large, multicenter, randomized controlled trial published in 2011. It found that annual screening with low-dose CT (LDCT) in a high-risk population was associated with a 20% reduction in lung cancer-specific mortality compared with conventional chest radiography. Several leading professional organizations have since put forth lung cancer screening guidelines that include the use of LDCT, largely on the basis of this study. Broad adoption of these screening recommendations, however, remains a challenge.

Keywords: Low-dose CT; Lung cancer; NLST; Screening.

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Conflict of interest statement

Conflicts of interest/disclosure statement:

All authors declare no conflicts of interest and have no disclosures to make.

Figures

Figure 1
Figure 1
Diagnoses, by Stage, for LDCT and CXR CXR, chest radiography; LDCT, low-dose computed tomography. Data from Aberle DR, Adams AM, Berg CD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365(5):395–409.
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