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. 1989 Sep 15;262(3):977-9.
doi: 10.1042/bj2620977.

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor

F Cajone  1 , M Salina, A Benelli-Zazzera
Affiliations

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor

F Cajone et al. Biochem J. .

Abstract

By using a gel mobility assay, we have shown that treatment of HeLa cells with 4-hydroxynonenal, a major product of the peroxidation of membrane lipids and an inducer of heat-shock proteins, has the same effect as heat shock in causing the appearance of a protein which binds to the sequence of DNA specific for the induction of heat-shock genes. Lipoperoxidation and heat exposure seem to share a common mechanism of specific gene activation.

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