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Comment
. 2015 Apr 28;112(17):5267-8.
doi: 10.1073/pnas.1505170112. Epub 2015 Apr 20.

Preventing peptide and protein misbehavior

Paolo Arosio  1 , Georg Meisl  1 , Maria Andreasen  1 , Tuomas P J Knowles  2
Affiliations
Comment

Preventing peptide and protein misbehavior

Paolo Arosio et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The application of chemical kinetic analysis enables crucial advances in the understanding of the microscopic mechanisms of inhibition of compounds against the misassembly of peptides and proteins (15). (A) Several systems are emerging where a molecular modulator interferes with the aggregation of peptides and proteins by inhibiting specifically an individual microscopic event in the global reaction process. (B) This behavior can be identified by analyzing the corresponding characteristic changes in the macroscopic kinetic profiles. In PNAS, Abelein et al. (7) show that the zinc ion has a protective role against the formation of fibrils from the Aβ peptide, which is closely associated with Alzheimer's disease, and that this activity of the metal ion originates from the specific inhibition of the elongation rate of fibrils by monomers (B, Center).
See this image and copyright information in PMC

Comment on

References

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