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Review
. 2015 Apr 23:13:13.
doi: 10.1186/s12969-015-0008-x.

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

Reut Gurion  1 , Vin Tangpricha  2   3 , Eric Yow  4 , Laura E Schanberg  5 , Grace A McComsey  6   7 , Angela Byun Robinson  8 ; Atherosclerosis Prevention in Pediatric Lupus Erythematosus Investigators
Collaborators, Affiliations
Review

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

Reut Gurion et al. Pediatr Rheumatol Online J. .

Abstract

Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities.

Trial registration: ClinicalTrials.gov identifier: NCT00065806.

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Figures

Figure 1
Figure 1
AVN in a SLE patient.
Figure 2
Figure 2
Osteonecrosis in a patient with acute myeloid leukemia.
Figure 3
Figure 3
Slipped capital femoral epiphysis (SCFE).
Figure 4
Figure 4
Legg-Calvé-Perthes’ disease (LCPD).
See this image and copyright information in PMC

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