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Comparative Study
. 1989 Apr;32(4):774-8.
doi: 10.1021/jm00124a008.

Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives

F M Arcamone  1 , F Animati, B Barbieri, E Configliacchi, R D'Alessio, C Geroni, F C Giuliani, E Lazzari, M Menozzi, N Mongelli
Affiliations
Comparative Study

Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives

F M Arcamone et al. J Med Chem. 1989 Apr.

Erratum in

  • J Med Chem 1989 Dec;32(12):2583

Abstract

A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin. All derivatives form complexes with native calf-thymus DNA but compounds 2, 3, and 6 give rise to covalent adducts. Cytostatic activity against both human and murine tumor cell lines in vitro is displayed by the new compounds. Compounds 3 and 4 are active on melphalan-resistant L1210 leukemia in mice.

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