Excess cardiovascular risk in diabetic women: a case for intensive treatment
- PMID: 25903071
- PMCID: PMC4408368
- DOI: 10.1007/s11906-015-0554-0
Excess cardiovascular risk in diabetic women: a case for intensive treatment
Abstract
Diabetes is a common and rapidly growing disease that affects more than 380 million people worldwide and is an established risk factor for cardiovascular disease with differential effects on women compared to men. While the general population of women, particularly young women, has more favourable cardiovascular risk profiles than men, this protective effect has been shown to be lost or even reversed in diabetic women. Several studies have demonstrated a significant diabetes-associated excess risk of cardiovascular disease in women. Sex-specific differences in risk factors associated with diabetes and their management may be responsible for the relative excess cardiovascular risk in women with diabetes. Diabetic women need intensive treatment in order to optimize management of cardiovascular risk factors. Further studies are needed to elucidate the mechanisms underlying the excess cardiovascular risk in diabetic women in order to tailor prevention and treatment strategies.
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References
-
- Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2 · 7 million participants. Lancet. 2011;378(9785):31–40. doi: 10.1016/S0140-6736(11)60679-X. - DOI - PubMed
-
- International Diabetes Federation. IDF Diabetes Atlas update poster, 6th edn. Brussels Belgium: International Diabetes Federation, 2014. http://www.idf.org/diabetesatlas
-
- WHO Estimates for 2000–2012 http://www.who.int/healthinfo/global_burden_disease/estimates/en/index1....
-
- International Diabetes Federation. IDF Diabetes Atlas, 6th edn. Brussels Belgium: International Diabetes Federation, 2013. http://www.idf.org/diabetesatlasThe International Diabetes Federation (IDF) is an umbrella organization of over 230 national diabetes associations in 170 countries and territories. The 6th Edition of the IDF Diabetes Atlas reports diabetes epidemiology using new studies that became available in 2013, and updated population estimates.
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