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Review
. 2015 Apr 20;20(4):7097-142.
doi: 10.3390/molecules20047097.

A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012

Wamtinga Richard Sawadogo  1   2 , Rainatou Boly  2 , Claudia Cerella  3 , Marie Hélène Teiten  4 , Mario Dicato  5 , Marc Diederich  6   7   8
Affiliations
Review

A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012

Wamtinga Richard Sawadogo et al. Molecules. .

Abstract

Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of agelasine B (1).
Figure 2
Figure 2
Chemical structure of granulatimide, isogranulatimide, and their analogs.
Figure 3
Figure 3
Chemical structure of bis(indolyl)hydrazide-hydrazone analogs.
Figure 4
Figure 4
Chemical structures of hyrtiorecticulins analogs.
Figure 5
Figure 5
Chemical structures of chromenoindole analogs.
Figure 5
Figure 5
Chemical structures of chromenoindole analogs.
Figure 6
Figure 6
Chemical structure of 5-(2,4-dimethylbenzyl) pyrrolidin-2-one (DMBPO, 18).
Figure 7
Figure 7
Biselyngbyasides 1, A, B, C, D.
Figure 8
Figure 8
Bryostatin-1 (24).
Figure 9
Figure 9
Eribulin (25).
Figure 10
Figure 10
Halichoblelides A, B, C.
Figure 11
Figure 11
Peloruside A and Laulimalide.
Figure 12
Figure 12
Mycoepoxydiene (MED, 31).
Figure 13
Figure 13
Salarins A, B, C.
Figure 14
Figure 14
Spirastrellolides A and B.
Figure 14
Figure 14
Spirastrellolides A and B.
Figure 15
Figure 15
Neamphamides B, C and D.
Figure 16
Figure 16
Viequeamide A.
Figure 17
Figure 17
Pipestelides A, B, C.
Figure 17
Figure 17
Pipestelides A, B, C.
Figure 18
Figure 18
Kulokekahilide-2 and its derivatives.
Figure 19
Figure 19
Lagunamide A and B.
Figure 20
Figure 20
Cordyheptapeptide C, D and E.
Figure 21
Figure 21
Structures of the carboxylate and acid forms of hoiamide D (59).
Figure 22
Figure 22
Protuboxepin A.
Figure 23
Figure 23
Aeroplysinin-1 (61).
Figure 24
Figure 24
Bis (2,3-dibromo-4,5-dihydroxybenzyl) ether (BBDE, 62).
Figure 25
Figure 25
Diphlorethohydroxycarmalol (DC, 63).
Figure 26
Figure 26
Grincamycin A, B, C, D, E, F.
Figure 27
Figure 27
Laminarin (70).
Figure 28
Figure 28
7-Hydroxycymopochromanone (PBQ1, 71) and 7-hydroxycymopolone (PBQ2, 72).
Figure 29
Figure 29
SZ-685C (73).
Figure 30
Figure 30
Hydroanthraquinones and anthraquinones dimers (74–84).
Figure 31
Figure 31
Alterporriol L (85).
Figure 32
Figure 32
Xestoquinones.
Figure 33
Figure 33
Aminoquinones and derivatives 93–96.
Figure 34
Figure 34
Bostrycin, deoxybostrycin and derivatives 97–102.
Figure 35
Figure 35
Secosterol analogs 103, 104.
Figure 36
Figure 36
Polyoxygenated steroid dysideasterol analogs.
Figure 37
Figure 37
11-Dehydrosinulariolide (110).
Figure 38
Figure 38
Diketosteroid, (E)-stigmasta-24(28)-en-3,6-dione (111), β-sitosterol (112), fucosterol (113) and saringosterol (114).
Figure 39
Figure 39
10-Acetylirciformonin B (115).
Figure 40
Figure 40
Phenazineanalogs 116–118.
Figure 41
Figure 41
Echinohalimane A (119).
Figure 42
Figure 42
(1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide (120).
Figure 43
Figure 43
Michaolides and derivatives 121–127.
Figure 44
Figure 44
Stellettin A (128).
Figure 45
Figure 45
Triterpene glycosides 129–131.
Figure 46
Figure 46
Hirsutanol A (132).
Figure 47
Figure 47
Chondrosterins A–E and hirsutanol C (133–138).
Figure 48
Figure 48
Anticancer compounds regrouped per family.
See this image and copyright information in PMC

References

    1. IARC . Cancer Incidence and Mortality Worlwide. International Agency for Research on Cancer; Lyon, France: 2011.
    1. WHO . Global Status Report on Noncommunicable Diseases 2010. WHO; Geneva, Switzerland: 2011. pp. 11–15.
    1. WHO Cancer: Fact Sheet N°297. [(accessed on 8 October 2014)]. Available online: http://www.who.int/mediacentre/factsheets/fs297/en/
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