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Case Reports
. 2015 Jul;53(7):2343-5.
doi: 10.1128/JCM.00502-15. Epub 2015 Apr 22.

High-Level Pan-Azole-Resistant Aspergillosis

Jakko van Ingen  1 , Henrich A L van der Lee  1 , Antonius J M M Rijs  1 , Eveline Snelders  1 , Willem J G Melchers  1 , Paul E Verweij  2
Affiliations
Case Reports

High-Level Pan-Azole-Resistant Aspergillosis

Jakko van Ingen et al. J Clin Microbiol. 2015 Jul.

Abstract

High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.

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References

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