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. 2015 May 15:282:73-9.
doi: 10.1016/j.jneuroim.2015.03.017. Epub 2015 Mar 21.

Amyloid beta-42 (Aβ-42), neprilysin and cytokine levels. A pilot study in patients with HIV related cognitive impairments

K M Mothapo  1 , F Stelma  2 , M Janssen  3 , R Kessels  3 , S Miners  4 , M M Verbeek  5 , P Koopmans  6 , A van der Ven  6
Affiliations

Amyloid beta-42 (Aβ-42), neprilysin and cytokine levels. A pilot study in patients with HIV related cognitive impairments

K M Mothapo et al. J Neuroimmunol. .

Abstract

HIV-associated dementia (HAD) is associated with amyloid-beta (Aβ) deposition. This study measured CSF and plasma amyloid beta-42 (Aβ-42), neprilysin (NEP) and cytokine levels in HIV-related cognitive impairments (HCI), HIV normal cognitive functioning (NF) and non-HIV controls. Our data showed a trend towards detectable plasma Aβ-42 levels more frequently in HCI (67%), when compared to NF (29%) and controls (10%). We showed elevated IL-8 levels in CSF of HCI compared to NF, although not significant values. The data from this pilot study indicates that CSF IL-8 and plasma Aβ-42 may be interesting biomarkers for the presence of HCI.

Keywords: Amyloid beta-42; Anti-inflammatory cytokines; HIV associated neurocognitive disorders; HIV related cognitive impairments; Neprilysin; Pro-inflammatory cytokines.

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