Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;45(9):2816-32.
doi: 10.1007/s10803-015-2443-4.

Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder

Angela John Thurman  1 , Andrea McDuffie, Sara T Kover, Randi J Hagerman, Leonard Abbeduto
Affiliations

Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder

Angela John Thurman et al. J Autism Dev Disord. 2015 Sep.

Abstract

Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Trajectory of social affect calibrated severity score relative to chronological age for boys with FXS and boys with nonsyndromic ASD.
Figure 2
Figure 2
Trajectory of social affect calibrated severity score relative to nonverbal cognitive ability for boys with FXS and boys with nonsyndromic ASD.
Figure 3
Figure 3
Trajectory of social affect calibrated severity score relative to expressive vocabulary ability for boys with FXS and boys with nonsyndromic ASD.
Figure 4
Figure 4
Trajectory of restrictive and repetitive behavior calibrated severity score relative to chronological age for boys with FXS and boys with nonsyndromic ASD.
Figure 5
Figure 5
Trajectory of restrictive and repetitive behavior calibrated severity score relative to nonverbal cognitive ability for boys with FXS and boys with nonsyndromic ASD.
Figure 6
Figure 6
Trajectory of restrictive and repetitive behavior calibrated severity score relative to expressive vocabulary ability for boys with FXS and boys with nonsyndromic ASD.
See this image and copyright information in PMC

References

    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th. Washington, DC: American Psychiatric Publishing; 2000. text revision.
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th. Arlington, VA: American Psychiatric Publishing; 2013.
    1. Bailey DB, Hatton DD, Mesibov G, Ament N, Skinner M. Early development, temperament, and functional impairment in autism and fragile X syndrome. Journal of Autism and Developmental Disorders. 2000;30:49–59. - PubMed
    1. Bailey DB, Hatton DD, Skinner M, Mesibov G. Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders. 2001;31:165–174. - PubMed
    1. Bailey DB, Mesibov GB, Hatton DD, Clark RD, Roberts JE, Mayhew L. Autistic behavior in young boys with fragile X syndrome. Journal of Autism and developmental Disorders. 1998;28:499–508. - PubMed

Publication types

LinkOut - more resources