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. 2015 Feb;44(2):211-7.

Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance

Neda Roshanravan  1 , Mohammad Alizadeh  2 , Mehdi Hedayati  3 , Mohammad Asghari-Jafarabadi  4 , Naimeh Mesri Alamdari  1 , Farideh Anari  5 , Ali Tarighat-Esfanjani  6
Affiliations

Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance

Neda Roshanravan et al. Iran J Public Health. 2015 Feb.

Abstract

Background: Hyperglycemia and gestational diabetes mellitus are complications of pregnancy. Both mothers and newborns are typically at increased risk for complications. This study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.

Methods: In this clinical trial 44 pregnant women with impaired glucose tolerance, from December 2012 -April 2013 were randomly divided into zinc (n=22) and placebo (n=22) groups and recived 30mg/day zinc gluconate and (n=22), and placebo for eight consecutive weeks respectively. Dietary food intake was estimated from 3-days diet records. Serum levels of zinc, fasting blood sugar, and insulin were measured by conventional methods. Also homeostatic model assessment of insulin resistance was calculated.

Results: Serumlevels of fasting blood sugar, insulin and homeostatic model assessment of insulin resistance slightly decreased in zinc group, but these changes were not statistically significant. Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group.

Conclusion: Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels.

Keywords: Energy; Impaired glucose tolerance; Insulin resistance; Zinc.

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Figures

Fig. 1:
Fig. 1:
Flowchart of design and protocol of the study
See this image and copyright information in PMC

References

    1. Test OGT. ( 2008). Hyperglycemia and adverse pregnancy outcomes. N Engl J Med, 358: 1991– 2002. - PubMed
    1. Farah N, McGoldrick A, Fattah C, et al. ( 2012). Body Mass Index (BMI) and Glucose Intolerance during Pregnancy in White European Women. J Reprod Infertil, 13( 2): pp. 95– 99. - PMC - PubMed
    1. O'Brien KO, Zavaleta N, Caulfield LE, et al. ( 2000). Prenatal iron supplements impair zinc absorption in pregnant Peruvian women. J Nutr, 130( 9): pp. 2251– 2255. - PubMed
    1. Abdolsamadi H, Zamani M, Goodarzi M, et al. ( 2012). Comparative Evaluation of Chromium and Cadmium in Gestational diabetes and healthy pregnant women. Iran J Endocrinol Metab, 13( 6): pp. 666– 672.
    1. Salimi S, Yaghmaei M, Joshaghani HR, Mansourian AR. ( 2004). Study of zinc deficiency in pregnant women. Iran J Public Health, 33( 3): pp. 15– 18.

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