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1 Department of Pharmacology, Clinical Pharmacology Unit, Hospital of the University of Cologne, Gleueler Straße 24, 50931, Köln, Germany. uwe.fuhr@uk-koeln.de.
2 Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Köln, Germany.
1 Department of Pharmacology, Clinical Pharmacology Unit, Hospital of the University of Cologne, Gleueler Straße 24, 50931, Köln, Germany. uwe.fuhr@uk-koeln.de.
2 Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Köln, Germany.