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Comparative Study
. 2015 Jul;82(3):201-2.
doi: 10.1016/j.diagmicrobio.2015.04.001. Epub 2015 Apr 7.

Potential risk of misclassification HCV 2k/1b strains as HCV 2a/2c using VERSANT HCV Genotype 2.0 assay

Steven De Keukeleire  1 , Patrick Descheemaeker  2 , Marijke Reynders  2
Affiliations
Comparative Study

Potential risk of misclassification HCV 2k/1b strains as HCV 2a/2c using VERSANT HCV Genotype 2.0 assay

Steven De Keukeleire et al. Diagn Microbiol Infect Dis. 2015 Jul.

Abstract

The performance of a hepatitis C virus (HCV) NS5B sequencing method described by Murphy et al. (Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5' untranslated region sequences. J Clin Microbiol 2007;45(4):1102-12.) was compared with the VERSANT HCV Genotype 2.0 assay. The sequencing strategy led to detection of HCV recombinant genotype 2k/1b, previously identified as genotype 2a/2c, which reveals the importance of exact HCV genotyping and subtyping.

Keywords: HCV 2k/1b; HCV genotyping and subtyping; Hepatitis C virus; Recombinant forms.

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