Where and what is the PPN and what is its role in locomotion?

Francois Windels¹, Wesley Thevathasan², Peter Silburn¹, Pankaj Sah³

Affiliations

¹ 1 Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia.
² 2 Melbourne Brain Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne and the Bionics Institute, Melbourne, Australia.
³ 1 Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia pankaj.sah@uq.edu.au.

PMID: 25907754
PMCID: PMC5963413
DOI: 10.1093/brain/awv059

Comment

Where and what is the PPN and what is its role in locomotion?

Francois Windels et al. Brain. 2015 May.

. 2015 May;138(Pt 5):1133-4.

doi: 10.1093/brain/awv059.

Authors

Francois Windels¹, Wesley Thevathasan², Peter Silburn¹, Pankaj Sah³

Affiliations

¹ 1 Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia.
² 2 Melbourne Brain Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne and the Bionics Institute, Melbourne, Australia.
³ 1 Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia pankaj.sah@uq.edu.au.

PMID: 25907754
PMCID: PMC5963413
DOI: 10.1093/brain/awv059

Abstract

This scientific commentary refers to ‘The integrative role of the pedunculopontine nucleus in human gait’, by Lau et al. (doi:10.1093/brain/awv047).

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Comment on

The integrative role of the pedunculopontine nucleus in human gait.
Lau B, Welter ML, Belaid H, Fernandez Vidal S, Bardinet E, Grabli D, Karachi C. Lau B, et al. Brain. 2015 May;138(Pt 5):1284-96. doi: 10.1093/brain/awv047. Epub 2015 Mar 12. Brain. 2015. PMID: 25765327 Free PMC article.

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References

1. Benabid AL, Chabardes S, Mitrofanis J, Pollak P. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurol. 2009;8:67–81. - PubMed
1. Ferraye MU, Debu B, Fraix V, Goetz L, Ardouin C, Yelnik J, et al. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease. Brain. 2010;133 (Pt 1):205–14. - PubMed
1. Fu RZ, Naushahi MJ, Adams A, Mehta A, Bain PG, Pavese N, et al. Sub-caudal pedunculopontine nucleus (PPN) deep brain stimulation (DBS) best predicts improvements in freezing of gait questionnaire (FOGQ) scores in Parkinson's disease patients. Mov Disord. 2014;29(Suppl 1):1193. - PubMed
1. Grillner S. Biological pattern generation: the cellular and computational logic of networks in motion. Neuron. 2006;52:751–66. - PubMed
1. Jahn K, Deutschlander A, Stephan T, Kalla R, Wiesmann M, Strupp M, et al. Imaging human supraspinal locomotor centers in brainstem and cerebellum. Neuroimage. 2008;39:786–92. - PubMed

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Where and what is the PPN and what is its role in locomotion?

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Where and what is the PPN and what is its role in locomotion?

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