Osteoblast ablation burns out functional stem cells
- PMID: 25907901
- DOI: 10.1182/blood-2015-03-633651
Osteoblast ablation burns out functional stem cells
Abstract
In this issue of Blood, Bowers et al report that osteoblasts maintain a subset of quiescent stem cells and that osteoblast ablation converts bone marrow into a proliferation-promoting environment for both normal and malignant stem cells.
Comment on
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Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development.Blood. 2015 Apr 23;125(17):2678-88. doi: 10.1182/blood-2014-06-582924. Epub 2015 Mar 5. Blood. 2015. PMID: 25742698 Free PMC article.