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Review
. 2015 May;6(5):322-33.
doi: 10.1007/s13238-015-0149-1. Epub 2015 Apr 25.

SIRTain regulators of premature senescence and accelerated aging

Shrestha Ghosh  1 , Zhongjun Zhou
Affiliations
Review

SIRTain regulators of premature senescence and accelerated aging

Shrestha Ghosh et al. Protein Cell. 2015 May.

Abstract

The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed.

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Figures

Figure 1
Figure 1
Schematic representation showing the regulation of premature aging by sirtuins via multiple biological processes
See this image and copyright information in PMC

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