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Review
. 2014 Jul;43(7):877-88.

Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis

Wei Wang  1 , Ping Li  1 , Yifei Chen  1 , Jiong Yang  1
Affiliations
Free PMC article
Review

Association between β2-Adrenergic Receptor-16Arg/Gly Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis

Wei Wang et al. Iran J Public Health. 2014 Jul.
Free PMC article

Abstract

Background: The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship.

Methods: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, VIP) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association.

Results: Eleven studies, comprising 1,128 COPD patients and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the ADRB2-16Arg/Gly polymorphism and COPD risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians under the dominant genetic model and allele model (Arg vs. Gly) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups.

Conclusion: This meta-analysis suggested that the ADRB2-16Arg/Gly polymorphism might be a potential risk factor for the development of COPD in smoking Asian populations, but not in European descendents, and tobacco smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

Keywords: COPD; Meta-analysis; Tobacco smoking; rs1042713; β2-adrenergic receptor.

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Figures

Fig. 1
Fig. 1
Flow diagram of the meta-analysis
Fig. 2
Fig. 2
Forest plot for the association between ADRB2-16Arg/Gly and COPD risk under the dominant genetic model. High heterogeneity was existing among studies and the random-effects model was performed
Fig. 3
Fig. 3
Forest plot for the association between ADRB2-16Arg/Gly and COPD risk among smoking Asians under allele and dominant genetic models. (A) dominant model, (B) allele model, fixed-effects model was used
Fig. 4
Fig. 4
Sensitivity analysis for the association between the ADRB2-16Arg/Gly polymorphism and COPD risk among smoking Asians. Each circle and transverse line represented the pooled OR and 95% CI by deleting the corresponding study
Fig. 5
Fig. 5
Begg’s funnel plot for publication bias of studies under dominant model. Each circle represented a corresponding study
See this image and copyright information in PMC

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