Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989;25(1):73-4.
doi: 10.1007/BF00694343.

Phase II study of mitoxantrone for liver metastases from breast cancer

S M O'Reilly  1 , R E Coleman, R D Rubens
Affiliations

Phase II study of mitoxantrone for liver metastases from breast cancer

S M O'Reilly et al. Cancer Chemother Pharmacol. 1989.

Abstract

Mitoxantrone was given to 19 patients with liver metastases from breast cancer and biochemical evidence of liver dysfunction. In all, 2 patients received the drug at a dose of 10 mg/m2 on days 1 and 2 of the first course of treatment; 1 patient was given 9 mg/m2 and 17 received 8 mg/m2. Subsequent courses were given at a dose of 10 mg/m2. Three patients (16%) showed a partial response, with time to progression of between 3 and 7 months. Toxicity was considerable, with myelosuppression being the major problem.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Med Oncol Tumor Pharmacother. 1984;1(3):169-92 - PubMed
    1. Br J Cancer. 1987 Jan;55(1):61-6 - PubMed
    1. Eur J Cancer Clin Oncol. 1984 Sep;20(9):1141-6 - PubMed
    1. Clin Pharmacol Ther. 1982 Mar;31(3):312-6 - PubMed
    1. Cancer. 1981 Jan 1;47(1):207-14 - PubMed

LinkOut - more resources