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. 2015 Apr 23;161(3):429-430.
doi: 10.1016/j.cell.2015.04.006.

Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing

Gheorghe Chistol  1 , Johannes C Walter  2
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Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing

Gheorghe Chistol et al. Cell. .
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Abstract

The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication.

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