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Review
. 2015 May;145(1):5-15.
doi: 10.1093/toxsci/kfv040.

Polycyclic aromatic hydrocarbons: from metabolism to lung cancer

Bhagavatula Moorthy  1 , Chun Chu  1 , Danielle J Carlin  1
Affiliations
Review

Polycyclic aromatic hydrocarbons: from metabolism to lung cancer

Bhagavatula Moorthy et al. Toxicol Sci. 2015 May.

Abstract

Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer, a disease with the highest cancer mortality in the United States. After entry into the lung, PAHs induce phase I metabolic enzymes such as cytochrome P450 (CYP) monooxygenases, i.e. CYP1A1/2 and 1B1, and phase II enzymes such as glutathione S-transferases, UDP glucuronyl transferases, NADPH quinone oxidoreductases (NQOs), aldo-keto reductases (AKRs), and epoxide hydrolases (EHs), via the aryl hydrocarbon receptor (AhR)-dependent and independent pathways. Humans can also be exposed to PAHs through diet, via consumption of charcoal broiled foods. Metabolism of PAHs through the CYP1A1/1B1/EH pathway, CYP peroxidase pathway, and AKR pathway leads to the formation of the active carcinogens diol-epoxides, radical cations, and o-quinones. These reactive metabolites produce DNA adducts, resulting in DNA mutations, alteration of gene expression profiles, and tumorigenesis. Mutations in xenobiotic metabolic enzymes, as well as polymorphisms of tumor suppressor genes (e.g. p53) and/or genes involved in gene expression (e.g. X-ray repair cross-complementing proteins), are associated with lung cancer susceptibility in human populations from different ethnicities, gender, and age groups. Although various metabolic activation/inactivation pathways, AhR signaling, and genetic susceptibilities contribute to lung cancer, the precise points at which PAHs induce tumor initiation remain unknown. The goal of this review is to provide a current state-of-the-science of the mechanisms of human lung carcinogenesis mediated by PAHs, the experimental approaches used to study this complex class of compounds, and future directions for research of these compounds.

Keywords: Ah receptor; PAH; carcinogenesis; genetic susceptibility; lung cancer; metabolism; mixtures; polycyclic aromatic hydrocarbons.

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Figures

FIG. 1.
FIG. 1.
Major sources through which PAH exposure occurs in humans.
FIG. 2.
FIG. 2.
Chemical structure of PAHs.
FIG. 3.
FIG. 3.
Major pathways of metabolic activation of the PAH BaP to DNA-binding metabolites.
FIG. 4.
FIG. 4.
Multiple mechanisms by which PAHs cause lung cancer.
See this image and copyright information in PMC

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