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. 1989 Jul-Aug;12(4 Suppl):209S-214S.
doi: 10.1016/0732-8893(89)90138-7.

In vitro assessment of sulbactam plus cefoperazone in the treatment of bacteria isolated from cancer patients

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In vitro assessment of sulbactam plus cefoperazone in the treatment of bacteria isolated from cancer patients

G P Bodey et al. Diagn Microbiol Infect Dis. 1989 Jul-Aug.

Abstract

Cefoperazone is a broad-spectrum cephalosporin that has been used extensively to treat infections in cancer patients. A recent survey demonstrated only a 6% resistance to this drug among Gram-negative bacteria. The combination of cefoperazone plus sulbactam was studied in vitro against consecutive isolates causing bacteremia in cancer patients as well as those selected for resistance to cefoperazone. Both a fixed ratio of sulbactam/cefoperazone (2:1 w/w) and selected concentrations of sulbactam (2, 4, 8, and 16 micrograms/ml) were studied. Sulbactam was shown to increase the susceptibility of various unselected Gram-negative bacilli; this effect increased with larger concentrations of sulbactam. The addition of sulbactam at optimum concentration levels made 29 of 65 cefoperazone-resistant Gram-negative bacilli susceptible. This effect was seen most markedly for Acinetobacter spp.

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