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Review
. 2015 Aug;17(8):549-56.
doi: 10.1016/j.micinf.2015.04.004. Epub 2015 Apr 22.

Infection, systemic inflammation, and Alzheimer's disease

Siok Lam Lim  1 , Carlos J Rodriguez-Ortiz  1 , Masashi Kitazawa  2
Affiliations
Free article
Review

Infection, systemic inflammation, and Alzheimer's disease

Siok Lam Lim et al. Microbes Infect. 2015 Aug.
Free article

Abstract

Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age.

Keywords: Alzheimer's disease; Environment; Infection; Inflammation; Risk factors; Sporadic.

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