Prevention of pertussis through adult vaccination

Abstract

Pertussis is a vaccine preventable respiratory infection. Young infants are at high risk of developing severe complications from infection. Despite high rates of pediatric vaccine uptake, there continues to be increases in pertussis cases, likely due to waning immunity from childhood vaccine and increased transmission through adults. Currently, pertussis booster vaccine (Tdap) is recommended for unimmunized adults and for women in the third trimester of each pregnancy; yet adult Tdap coverage remains low. Administering Tdap vaccine at non-traditional vaccination clinics and at sites where adults are accessing care for their children are effective in improving adult Tdap uptake. While most are willing to receive vaccine when recommended by their provider, lack of provider recommendation is a major obstacle to immunization. Future studies to understand barriers to provider vaccine recommendations need to be undertaken to develop interventions to improve adult Tdap vaccine uptake and reduce pertussis infection in the susceptible population.

Keywords: ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; Tdap; Tdap, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis; adult vaccination; cocooning; pertussis; pertussis vaccine; vaccines in pregnancy.