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. 1989 Dec 20;8(13):4073-80.
doi: 10.1002/j.1460-2075.1989.tb08591.x.

A 6000 kb segment of chromosome 1 is conserved in human and mouse

S F Kingsmore  1 , M L Watson, T A Howard, M F Seldin
Affiliations

A 6000 kb segment of chromosome 1 is conserved in human and mouse

S F Kingsmore et al. EMBO J. .

Abstract

A murine linkage map generated from analyses of 428 meiotic events in an interspecific cross and pulsed field gel electrophoresis allowed examination of the genomic organization of a 6000 kb segment of mouse and human chromosome 1. Analysis of five genes within this syntenic segment of both species revealed striking conservation of gene order, intergenic distance and, to a lesser extent, CpG dinucleotides. In the mouse, meiotic crossover events were not evenly distributed; a hot spot for meiotic recombination was coincident with a CpG-island. These studies provide a practical approach to aid physical mapping of the human genome and a model for determining the molecular principles that govern meiotic recombination. In addition, these findings demonstrate profound conservation of genomic organization over mammalian evolution.

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References

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