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. 2015 Oct 12;54(42):12357-60.
doi: 10.1002/anie.201502418. Epub 2015 Apr 27.

Cobalt-catalyzed hydrogenation of esters to alcohols: unexpected reactivity trend indicates ester enolate intermediacy

Dipankar Srimani  1   2 , Arup Mukherjee  1 , Alexander F G Goldberg  1 , Gregory Leitus  3 , Yael Diskin-Posner  3 , Linda J W Shimon  3 , Yehoshoa Ben David  1 , David Milstein  4
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Cobalt-catalyzed hydrogenation of esters to alcohols: unexpected reactivity trend indicates ester enolate intermediacy

Dipankar Srimani et al. Angew Chem Int Ed Engl. .

Abstract

The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with precious-metal-based catalysts, with few exceptions. Presented here is the first cobalt-catalyzed hydrogenation of esters to the corresponding alcohols. Unexpectedly, the evidence indicates the unprecedented involvement of ester enolate intermediates.

Keywords: alcohols; cobalt; esters; homogeneous catalysis; hydrogenation.

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