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Review
. 2015 Apr 21;21(15):4750-6.
doi: 10.3748/wjg.v21.i15.4750.

Helicobacter pylori infection and inflammatory bowel disease in Asians: a meta-analysis

Xiao-Wei Wu  1 , Hong-Zan Ji  1 , Miao-Fang Yang  1 , Lin Wu  1 , Fang-Yu Wang  1
Affiliations
Review

Helicobacter pylori infection and inflammatory bowel disease in Asians: a meta-analysis

Xiao-Wei Wu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the relationship between Helicobacter pylori infection and inflammatory bowel disease (IBD) in an Asian population.

Methods: The PubMed, EMBASE, and Cochrane Library databases were searched for observational studies published up until June 2014, without language restrictions. Additional references were obtained from reviewed articles.

Results: Ten studies involving 1299 IBD patients and 1817 controls were included in the meta-analysis (24.9% of IBD patients had H. pylori infection vs 48.3% of the controls). The pooled risk ratio for H. pylori infection in IBD patients compared with controls was 0.48 (95%CI: 0.43-0.54; P < 0.001). There was no significant heterogeneity in the included studies (I (2) = 21%). Egger's linear regression indicated that there was no significant publication bias (P = 0.203).

Conclusion: The H. pylori infection rate in Asian IBD patients is significantly lower than in non-IBD patients, indicating that infection protects against the development of IBD.

Keywords: Asian population; Crohn’s disease; Helicobacter pylori; Inflammatory bowel disease; Meta-analysis; Ulcerative colitis.

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Figures

Figure 1
Figure 1
Flow diagram of the study selection process.
Figure 2
Figure 2
Forest plot of Helicobacter pylori infection rate in inflammatory bowel disease vs control groups.
Figure 3
Figure 3
Forest plot of Helicobacter pylori infection rate in Crohn’s disease vs control groups.
Figure 4
Figure 4
Forest plot of Helicobacter pylori infection rate in ulcerative colitis vs control groups.
Figure 5
Figure 5
Funnel plot analysis.
See this image and copyright information in PMC

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MeSH terms