Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jan 28;35(4):403-14.
doi: 10.1038/onc.2015.109. Epub 2015 Apr 27.

The oncogene ERG: a key factor in prostate cancer

P Adamo  1 , M R Ladomery  2
Affiliations
Review

The oncogene ERG: a key factor in prostate cancer

P Adamo et al. Oncogene. .

Abstract

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG's oncogenic potential is well known because of its involvement in Ewing's sarcoma and leukaemia. However, in the past decade ERG has become highly associated with prostate cancer development, particularly as a result of a gene fusion with the promoter region of the androgen-induced TMPRRSS2 gene. We review ERG's structure and function, and its role in prostate cancer. We discuss potential new therapies that are based on targeting ERG.

PubMed Disclaimer

References

    1. Oncogene. 1995 Apr 6;10 (7):1423-30 - PubMed
    1. Oncogene. 2008 Mar 27;27(14 ):1993-2003 - PubMed
    1. Biochem Biophys Res Commun. 2005 Jul 15;332(4):1107-14 - PubMed
    1. Prostate. 2012 Oct 1;72(14):1514-22 - PubMed
    1. Mol Cell Biol. 1996 Jul;16(7):3338-49 - PubMed

Publication types

MeSH terms