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Comment
. 2015 May;47(5):427-8.
doi: 10.1038/ng.3290.

Keeping methylation at bay

Gavin Kelsey  1
Affiliations
Comment

Keeping methylation at bay

Gavin Kelsey. Nat Genet. 2015 May.

Abstract

A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.

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