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Comment
. 2015 Jun;11(6):326-8.
doi: 10.1038/nrneph.2015.66. Epub 2015 Apr 28.

Sepsis: Revising definitions of sepsis

Anne M Drewry  1 , Richard S Hotchkiss  1
Affiliations
Comment

Sepsis: Revising definitions of sepsis

Anne M Drewry et al. Nat Rev Nephrol. 2015 Jun.

Abstract

The traditional definition of sepsis requires the presence of at least two systemic inflammatory response syndrome (SIRS) criteria in addition to a suspected or proven infection. A recent large retrospective study, however, suggests that the requirement for two SIRS criteria excludes one in eight patients with severe sepsis.

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Figures

Figure 1
Figure 1
Relationship between infection, SIRS, organ failure and severe sepsis. a | The traditional model requires at least two SIRS criteria, infection and organ failure for a diagnosis of severe sepsis. b | A revised model allows for the presence of severe sepsis in the absence of SIRS criteria. Abbreviation: SIRS, systemic inflammatory response syndrome.
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Comment on

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