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. 2015 May 25;51(42):8805-8.
doi: 10.1039/c5cc02736e.

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

Xiao-Yun Deng  1 , Jin-Hong Lin, Jian Zheng, Ji-Chang Xiao
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Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

Xiao-Yun Deng et al. Chem Commun (Camb). .

Abstract

Difluoromethylation of the activated X-H bond (X = N, O and S) and aliphatic thiols, and gem-difluorocyclopropenation of alkynes with difluorocarbene generated in situ from difluoromethylene phosphobetaine (Ph3P(+)CF2CO2(-)) by decarboxylation occurred smoothly without the presence of any base or other additives.

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