Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr-Jun;33(2):142-9.
doi: 10.1016/j.rpped.2014.09.005. Epub 2015 Mar 28.

[Persistence of hepatitis A virus antibodies after primary immunization and response to revaccination in children and adolescents with perinatal HIV exposure]

[Article in Portuguese]
Aída de Fátima Thomé Barbosa Gouvêa  1 , Maria Isabel de Moraes Pinto  2 , Maristela Miyamoto  2 , Daisy Maria Machado  2 , Silvana Duarte Pessoa  3 , Fabiana Bononi do Carmo  2 , Suênia Cordeiro de Vasconcelos Beltrão  2 , Regina Célia de Menezes Succi  2
Affiliations

[Persistence of hepatitis A virus antibodies after primary immunization and response to revaccination in children and adolescents with perinatal HIV exposure]

[Article in Portuguese]
Aída de Fátima Thomé Barbosa Gouvêa et al. Rev Paul Pediatr. 2015 Apr-Jun.

Abstract

OBJECTIVE:: To assess possible factors associated with the loss of antibodies to hepatitis A 7 years after the primary immunization in children of HIV-infected mothers and the response to revaccination in patients seronegative for hepatitis A.

METHODS:: Quantification of HAV antibodies by electrochemiluminescence was performed in 39 adolescents followed up at the Pediatric Aids Clinic of Federal University of São Paulo (Unifesp): 29 HIV-infected (HIV group) (median age: 12.8 years) and 10 HIV-exposed but non-infected (ENI group) (median age: 13.4 years). All of them received two doses of HAV vaccine (Havrix(r)) in 2002.

RESULTS:: The median age at primary immunization (PI) was 5.4 years for HIV group and 6.5 years for ENI group. All children, from both groups, had antibodies to HAV >20 mIU/mL after PI. Seven years later, the ENI group showed a median concentration of antibodies = 253.5 mIU/mL, while the HIV group = 113.0 mIU/mL (Mann-Whitney test, p=0.085). All ENI group and 23/29 (79.3%) from HIV group mantained HAV antibodies 7 years after PI. The levels of hepatitis A antibodies in the primary vaccination were the only factor independently associated with maintaining these antibodies for 7 years. The group that lost HAV seropositivity was revaccinated and 83.3% (5/6) responded with antibodies >20 mUI/mL.

CONCLUSIONS:: The antibodies levels acquired in the primary vaccination in the HIV group were the main factor associated with antibodies loss after HAV immunization.

Keywords: Adolescent and children; Crianças e adolescentes; HIV; Hepatitis A vaccine; Immunossupression; Imunossupressão; Vacina de hepatite A.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.. Hepatitis A Antibodies in HIV Group and ENI Group 30 days and 7 years after primary immunization.
Figure 2.
Figure 2.. Dynamics of plasma levels of hepatitis A antibodies after revaccination in 6 patients from the HIV group without protective antibody levels seven years after primary immunization. Note: the sample from child #6 immediately before the 2nd booster dose was lost.
Figure 3.
Figure 3.. Evolution of viral load at four different moments: 30 days after primary vaccination (PV), seven years after PV, immediately before the 1st and 2nd booster dose (REVAC) in 6 patients from the HIV group who did not respond to revaccination.
Figure 4.
Figure 4.. CD4+ T cell count evolution at four different time: 30 days after primary vaccination (PV), 7 years after PV, immediately before the 1st and 2nd booster doses (REVAC) in 6 patients from the HIV group who did not respond to revaccination.
Figura 1.
Figura 1.. Anticorpos contra hepatite A no Grupo HIV e no Grupo ENI 30 dias e sete anos após imunização primária.
Figura 2.
Figura 2.. Dinâmica dos níveis plasmáticos dos anticorpos contra hepatite A após a revacinação nos seis pacientes do grupo HIV sem níveis protetores de anticorpos sete anos após a imunização primária. Observação: a amostra da criança 6 imediatamente antes da 2ª dose de revacinação foi perdida.
Figura 3.
Figura 3.. Evolução da carga viral, em quatro momentos: 30 dias após vacinação primária (VP), sete anos após VP, imediatamente antes da 1a e da 2a doses da revacinação (revac) nos seis pacientes do grupo HIV que não responderam à revacinação.
Figura 4.
Figura 4.. Evolução da contagem de células T CD4+ em quatro momentos: 30 dias após vacinação primária (VP), sete anos após VP, imediatamente antes da 1a e da 2a doses da revacinação (revac) nos seis pacientes do grupo HIV que não responderam à revacinação.
See this image and copyright information in PMC

References

    1. Brady MT, Oleske JM, Williams PL, Elgie C, Mofenson LM, Dankner WM, et al. Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era. J Acquir Immune Defic Syndr. 2010;53:86-94. - PMC - PubMed
    2. Brady MT, Oleske JM, Williams PL, Elgie C, Mofenson LM, Dankner WM. Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era. J Acquir Immune Defic Syndr. 2010;53:86–94. - PMC - PubMed
    1. Matida LH, Ramos AN Jr, Heukelbach J, Hearst N, Brazilian Study Group on Survival of Children with Aids. Continuing improvement in survival for children with acquired immunodeficiency syndrome in Brazil. Pediatr Infect Dis J. 2009;28:920-2. - PubMed
    2. Matida LH, Ramos AN, Jr, Heukelbach J, Hearst N, Brazilian Study Group on Survival of Children with Aids Continuing improvement in survival for children with acquired immunodeficiency syndrome in Brazil. Pediatr Infect Dis J. 2009;28:920–922. - PubMed
    1. Sutcliffe CG, Moss WJ. Do children infected with HIV receiving Haart need to be revaccinated? Lancet Infect Dis. 2010;10:630-42. - PubMed
    2. Sutcliffe CG, Moss WJ. Do children infected with HIV receiving Haart need to be revaccinated. Lancet Infect Dis. 2010;10:630–642. - PubMed
    1. Costa-Mattioli M, Allavena C, Poirier AS, Billaudel S, Raffi F, Ferré V. Prolonged hepatitis A infection in an HIV-1 seropositive patient. J Med Virol. 2002;68:7-11. - PubMed
    2. Costa-Mattioli M, Allavena C, Poirier AS, Billaudel S, Raffi F, Ferré V. Prolonged hepatitis A infection in an HIV-1 seropositive patient. J Med Virol. 2002;68:7–11. - PubMed
    1. Ridolfo AL, Rusconi S, Antinori S, Balotta C, Galli M. Persisting HIV-1 replication triggered by acute hepatitis A virus infection. Antivir Ther. 2000;5:15-7. - PubMed
    2. Ridolfo AL, Rusconi S, Antinori S, Balotta C, Galli M. Persisting HIV-1 replication triggered by acute hepatitis A virus infection. Antivir Ther. 2000;5:15–17. - PubMed

Substances