Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul;59(7):4336-8.
doi: 10.1128/AAC.00120-15. Epub 2015 Apr 27.

Two novel Salmonella genomic island 1 variants in Proteus mirabilis isolates from swine farms in China

Chang-Wei Lei  1 , An-Yun Zhang  1 , Bi-Hui Liu  1 , Hong-Ning Wang  2 , Li-Qin Yang  3 , Zhong-Bin Guan  1 , Chang-Wen Xu  1 , Dong-Dong Zhang  1 , Yong-Qiang Yang  1
Affiliations

Two novel Salmonella genomic island 1 variants in Proteus mirabilis isolates from swine farms in China

Chang-Wei Lei et al. Antimicrob Agents Chemother. 2015 Jul.

Abstract

Four different Salmonella genomic island 1 (SGI1) variants, including two novel variants, were characterized in one Salmonella enterica serovar Rissen sequence type ST1917 isolate and three Proteus mirabilis isolates from swine farms in China. One novel variant was derived from SGI1-B with the backbone gene S021 disrupted by a 12.72-kb IS26 composite transposon containing the dfrA17-aadA5 cassettes and macrolide inactivation gene cluster mphA-mrx-mphR. The other one was an integron-free SGI1 and contained a 183-bp truncated S025 next to IS6100 and S044.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Schematic view of the two novel SGI1 variants characterized in this study. Genes and open reading frames (orfs) are shown as arrows, and their orientations of transcription are indicated by the arrowheads. DR-L and DR-R represent the 18-bp direct repeats at the ends of SGI1. CS, conserved segment; IRi and IRt, inverted repeats defining the left and right hands of the integron.
See this image and copyright information in PMC

References

    1. Boyd D, Peters GA, Cloeckaert A, Boumedine KS, Chaslus-Dancla E, Imberechts H, Mulvey MR. 2001. Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J Bacteriol 183:5725–5732. doi: 10.1128/JB.183.19.5725-5732.2001. - DOI - PMC - PubMed
    1. Threlfall EJ. 2000. Epidemic Salmonella typhimurium DT 104—a truly international multiresistant clone. J Antimicrob Chemother 46:7–10. doi: 10.1093/jac/46.1.7. - DOI - PubMed
    1. Hall RM. 2010. Salmonella genomic islands and antibiotic resistance in Salmonella enterica. Future Microbiol 5:1525–1538. doi: 10.2217/fmb.10.122. - DOI - PubMed
    1. Ahmed AM, Hussein AI, Shimamoto T. 2007. Proteus mirabilis clinical isolate harbouring a new variant of Salmonella genomic island 1 containing the multiple antibiotic resistance region. J Antimicrob Chemother 59:184–190. doi: 10.1093/jac/dkl471. - DOI - PubMed
    1. Boyd DA, Shi X, Hu QH, Ng LK, Doublet B, Cloeckaert A, Mulvey MR. 2008. Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in Proteus mirabilis clinical and food isolates from China. Antimicrob Agents Chemother 52:340–344. doi: 10.1128/AAC.00902-07. - DOI - PMC - PubMed

Publication types

Substances

LinkOut - more resources