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Case Reports
. 2015 Jul;93(1):94-6.
doi: 10.4269/ajtmh.15-0077. Epub 2015 Apr 27.

Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection

Isaac I Bogoch  1 , Kamran Khan  2 , Howard Abrams  2 , Caroline Nott  2 , Elizabeth Leung  2 , Lawrence Fleckenstein  2 , Jay S Keystone  2
Affiliations
Case Reports

Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection

Isaac I Bogoch et al. Am J Trop Med Hyg. 2015 Jul.

Abstract

Two cases of Strongyloides hyperinfection are presented. Ivermectin was initially administered orally and per rectum pending the availability of subcutaneous (SC) preparations. In neither case did rectal suppositories of ivermectin achieve clinically meaningful serum values. Clinicians should use SC preparations of ivermectin as early as possible in Strongyloides hyperinfection and dissemination.

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