Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr-Jun;9(1):9-16.
doi: 10.22074/ijfs.2015.4202. Epub 2015 Apr 21.

Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy

Ziba Zahiri Sorouri  1 , Seyede Hajar Sharami  1 , Zinab Tahersima  1 , Fatemeh Salamat  2
Affiliations

Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy

Ziba Zahiri Sorouri et al. Int J Fertil Steril. 2015 Apr-Jun.

Abstract

Background: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of unilateral LOD (ULOD) versus bilateral LOD (BLOD) in CC resistance PCOS patients in terms of ovulation and pregnancy rates.

Materials and methods: In a prospective randomized clinical trial study, we included 100 PCOS patients with CC resistance attending to Al-Zahra Hospital in Rasht, Guilan Province, Iran, from June 2011 to July 2012. Patients were randomly divided into two ULOD and BLOD groups with equal numbers. The clinical and biochemical responses on ovulation and pregnancy rates were assessed over a 6-month follow-up period.

Results: Differences in baseline characteristics of patients between two groups prior to laparoscopy were not significant (p>0.05). There were no significant differences between the two groups in terms of clinical and biochemical responses, spontaneous menstruation (66.1 vs. 71.1%), spontaneous ovulation rate (60 vs. 64.4%), and pregnancy rate (33.1 vs. 40%) (p>0.05). Following drilling, there was a significant decrease in mean serum concentrations of luteinizing hormone (LH) (p=0.001) and testosterone (p=0.001) in both the groups. Mean decrease in serum LH (p=0.322) and testosterone concentrations (p=0.079) were not statistically significant between two groups. Mean serum level of follicle stimulating hormone (FSH) did not change significantly in two groups after LOD (p>0.05).

Conclusion: Based on results of this study, ULOD seems to be equally efficacious as BLOD in terms of ovulation and pregnancy rates (Registration Number: IRCT138903291306N2).

Keywords: Bilateral; Ovarian Induction; Polycystic Ovary Syndrome; Unilateral.

PubMed Disclaimer

Figures

Fig.1
Fig.1
Flowchart of randomized clinical trial for comparing ULOD versus BLOD in CC resistance PCOS patients. ULOD; Unilateral laparoscopic ovarian drilling, BLOD; Bilateral laparoscopic ovarian drilling, CC; Clomiphene citrate and PCOS; Polycystic ovary syndrome.
See this image and copyright information in PMC

References

    1. Abu Hashim H, Al-Inany H, De Vos M, Tournaye H. Three decades after Gjönnaess’s laparoscopic ovarian drilling for treatment of PCOS; what do we know?. An evidence-based approach. Arch Gynecol Obstet. 2013;288(2):409–422. - PubMed
    1. Costello MF, Misso ML, Wong J, Hart R, Rombauts L, Melder A, et al. The treatment of infertility in polycystic ovary syndrome: a brief update. Aust N Z J Obstet Gynaecol. 2012;52(4):400–403. - PubMed
    1. Hull MG. Epidemiology of infertility and polycystic ovarian: endocrinological and demographic studies. Gynecol Endocrinol. 1987;1(3):235–245. - PubMed
    1. Adam J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J (Clin Res Ed) 1986;293(6543):355–359. - PMC - PubMed
    1. Zolghadri J, Motazedian S, Dehbashi S, Tavana Z. Laparoscopic ovarian drilling inclomiphene resistant pco patients: a preferred method of treatment. Med J Islam Repub Iran. 2005;19(3):237–240.

LinkOut - more resources