Toxicological data after heroin overdose
- PMID: 2591990
- DOI: 10.1177/096032718900800609
Toxicological data after heroin overdose
Abstract
Capillary gas chromatography with selective nitrogen detection was employed to quantify morphine and 6-monoacetylmorphine in biological fluids and tissues in five deaths attributed to heroin injection overdose. The minimum lethal concentration found was 0.021 micrograms morphine per ml of blood. In all cases, 6-monoacetylmorphine was identified in urine, confirming heroin abuse.
Similar articles
-
Concentrations of heroin, 06-monoacetylmorphine, and morphine in a lethal case following an oral heroin overdose.J Anal Toxicol. 1997 May-Jun;21(3):232-5. doi: 10.1093/jat/21.3.232. J Anal Toxicol. 1997. PMID: 9171210
-
Distribution of free and conjugated morphine in body fluids and tissues in a fatal heroin overdose: is conjugated morphine stable in postmortem specimens?J Forensic Sci. 1997 Jul;42(4):736-40. J Forensic Sci. 1997. PMID: 9243843
-
Urinary excretion profiles for total morphine, free morphine, and 6-acetylmorphine following smoked and intravenous heroin.J Anal Toxicol. 2001 Oct;25(7):504-14. doi: 10.1093/jat/25.7.504. J Anal Toxicol. 2001. PMID: 11599592
-
Concentrations of free-morphine in peripheral blood after recent use of heroin in overdose deaths and in apprehended drivers.Forensic Sci Int. 2012 Feb 10;215(1-3):18-24. doi: 10.1016/j.forsciint.2011.01.043. Epub 2011 Feb 24. Forensic Sci Int. 2012. PMID: 21353406
-
Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature.Curr Clin Pharmacol. 2006 Jan;1(1):109-18. doi: 10.2174/157488406775268219. Curr Clin Pharmacol. 2006. PMID: 18666382 Review.
Cited by
-
Heroin overdose: research and evidence-based intervention.J Urban Health. 2003 Jun;80(2):189-200. doi: 10.1093/jurban/jtg022. J Urban Health. 2003. PMID: 12791795 Free PMC article. Review.
-
6-Monoacetylmorphine-antibody distribution in tissues from heroin-related death cases: An experimental study to investigate the distributive response.J Cell Mol Med. 2022 Sep;26(17):4666-4677. doi: 10.1111/jcmm.17351. Epub 2022 Aug 2. J Cell Mol Med. 2022. PMID: 35916437 Free PMC article.
-
Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.Forensic Toxicol. 2016;34:12-40. doi: 10.1007/s11419-015-0294-5. Epub 2015 Oct 28. Forensic Toxicol. 2016. PMID: 26793276 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources