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. 2016 Apr:38 Suppl 1:E815-9.
doi: 10.1002/hed.24106. Epub 2015 Jul 15.

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis

Rosario Mazzola  1   2 , Francesco Ricchetti  1 , Sergio Fersino  1 , Alba Fiorentino  1 , Niccolò Giaj Levra  1 , Gioacchino Di Paola  3 , Ruggero Ruggieri  1 , Filippo Alongi  1
Affiliations

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis

Rosario Mazzola et al. Head Neck. 2016 Apr.

Abstract

Background: The purpose of this study was to assess predictors of mucositis in oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric modulated arc radiotherapy (VMAT) +/- chemotherapy.

Methods: Fifty patients were evaluated. Statistical analysis was performed for the following parameters as potential predictors of mucositis ≥ G2: total oral mucosa and oral mucosa minus target high-low radiation dose regions (planning target volumes [PTVs]), mean dose (Dmean ), maximum dose (Dmax ), chemotherapy, weight loss, and dysphagia.

Results: Mucositis ≥ G2 was found to be statistically related to chemotherapy, weight loss, dysphagia ≥ G2, total oral mucosa Dmean ≥50 Gy and Dmax ≥65 Gy, V45 Gy >40%, V50 Gy >30%, and V55 Gy >20% of the oral mucosa minus target PTVs. A ratio between total oral mucosa and oral mucosa minus target PTVs >2.5 is related to G3 mucositis (p = .03).

Conclusion: New parameters were found as predictors of moderate-severe mucositis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E815-E819, 2016.

Keywords: head neck cancer; mucositis; organ sparing; volumetric modulated arc radiotherapy (VMAT).

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